Predicting early outcomes of liver transplantation in young children: The EARLY study

Table 2 Univariate and multiple linear regressions for the primary outcome of postoperative ventilator days after liver transplantation in n = 60 survivors

Variable	Univariate linear regression, n = 60		Multiple linear regression, n = 58
	Effect size (95%CI)	P-value	Effect size (95%CI)	P-value
Yr	-0.34 (-1.51, 0.83)	0.568
Weight	-1.36 (-3.06, 0.34)	0.114
PELD	0.03 (-0.30, 0.35)	0.866
Surgeon 2 vs 1	-0.77 (-8.69, 7.14)	0.845
Surgeon 3 vs 1	12.09 (3.15, 21.03)	0.009	10.67 (1.34, 20.01)	0.026
Surgeon 2 vs 3	-12.86 (-22.45, -3.28)	0.009	-9.69 (-19.24, -0.15)	0.047
Surgery duration, n = 541	-0.037 (-0.069, -0.005)	0.026
Fascia closed on admission	8.10 (0.52, 15.68)	0.037
Heparin started hour, n = 582	0.31 (0.17, 0.45)	0.001
Highest hemoglobin day 2-5	0.27 (0.001, 0.54)	0.049	0.22 (-0.04, 0.48)	0.096
Lowest anti-thrombin day 1, n = 44	-0.38 (-0.65, -0.11)	0.007
Lowest anti-thrombin day 2-5, n = 58	-0.35 (-0.57, -0.13)	0.003	-0.24 (-0.47, -0.02)	0.034
First day furosemide used, n = 521	1.01 (0.31, 1.70)	0.005
Graft type R/SL vs WL	-11.61 (-21.48, -1.74)	0.022	-12.53 (-21.82, -3.23)	0.009
Graft type LR vs WL	-9.27 (-18.73, 0.19)	0.055	-7.29 (-15.75, 1.17)	0.096

¹If we add “surgery duration” and “first day furosemide used” (n = 49) neither variable is significant, and if add only “first day furosemide used” also not significant;

²”Heparin started h” was not added to the multiple regression because it may be a marker of how worried the medical team are about bleeding vs thrombosis risk, and how long the INR is elevated [the correlation of “heparin started (h)” and “time for INR to be ≤ 2” is r = 0.66] (i.e., it may be an outcome, and not a determinant of outcome), and if added the effect size is 0.21 (0.07, 0.36); P = 0.005. INR: International normalized ratio; LR: Living related liver graft; PELD: Pediatric end-stage liver disease score; R/SL: Reduced or split liver graft; WL: Whole liver graft.