Current state and clinical outcome in Turkish patients with hepatocellular carcinoma

Table 4 Univariate and multivariate logistic regression analysis of factors associated with vascular invasion (n = 545, R² = 0.15)

Variables	Univariate			Multivariate
	OR	95%CI	P value	OR	95%CI	P value
TTD ≥ 5 cm	6.56	2.29-18.79	< 0.001	3.14	1.01-9.77	0.047
Tumor type
Solitary HCC	Reference	-	-	Reference	-	-
Multinodular HCC	2.07	1.01-4.25	0.047	1.54	0.72-3.30	0.270
Diffuse-infiltrative HCC	6.63	2.14-20.51	0.001	2.71	0.82-8.94	0.100
Extrahepatic metastasis	1.86	0.53-6.51	0.330
Etiology of liver disease
Hepatitis C	Reference	-	-	Reference	-	-
Hepatitis B	6.29	1.48-26.76	0.013	5.37	1.23-23.39	0.025
Other (non-viral)	4.52	0.89-22.91	0.069	3.76	0.72-19.74	0.120
Stage of liver disease
Normal or precirrhotic liver	Reference	-	-
Child-Pugh A	0.60	0.24-1.53	0.290
Child-Pugh B	0.53	0.18-1.52	0.240
Child-Pugh C	0.62	0.20-1.94	0.420
AFP level
> 100 ng/mL	3.77	1.79-7.96	< 0.001
> 200 ng/mL	4.18	2.05-8.52	< 0.001	2.95	1.38-6.31	0.005
> 400 ng/mL	2.81	1.43-5.52	0.003
> 1000 ng/mL	3.54	1.78-7.05	< 0.001

TTD: Total tumor diameter; HCC: Hepatocellular carcinoma; AFP: Alfa-fetoprotein.