Risk factors for hepatic steatosis in adults with cystic fibrosis: Similarities to non-alcoholic fatty liver disease

Table 1 Demographics of our patient sample

Feature	All subjects	Data by hepatic steatosis
		Hepatic steatosis	No steatosis	P value
No. of patients	114	17	97
Male/female	58/56	9/8	49/48	0.854
Median age at time of study (IQR)	29 (24-35)	27	29	0.981
Median BMI (IQR)	20.9 (19.3-24.9)	22.3	20.7	0.010a
Underweight (BMI < 18.5)	19	2	17	0.557
Overweight (BMI > 25)	28	8	20	0.019a
Genotype
ΔF508/ΔF508	57	11	46	0.216
ΔF508/other	44	6	38	0.714
Other	11	0	11	0.140
Unknown	2	0	2
ppFEV1	57 (36-76)	75	53	0.037a
Chronic pseudomonas colonization	80	14	66	0.234
Pancreatic insufficiency	92	15	77	0.394
Replacement dose	2011 (1334-2405)	1897	2012	0.610
Meconium ileus	26	4	22	0.939
CFRD	47	4	43	0.108
Hypertension	5	1	4	0.561
Hyperlipidemia	12	1	11	0.665
Any alcohol use	42	8	34	0.344
On CFTR modulator therapy	29	6	23	0.312

^aP < 0.05. IQR: Interquartile range; BMI: Body mass index; ppFEV1: Percent predicted forced expiratory volume in 1 s; CFRD: Cystic fibrosis related diabetes mellitus; CFTR: Cystic fibrosis transmembrane conductance regulator.