Epigenetic basis of hepatocellular carcinoma: A network-based integrative meta-analysis

Table 3 Clinicopathological information of the individual datasets and methodology used for methylation analysis

Dataset	Year	PMID	GEO dataset	HCC (n)	Controls (n)	Liver cirrhosis in HCC samples	Etiology of liver disease (n)	Method
1	2011	21500188		13	12	Y (12)	HBV (3), HCV (4), alcoholic (6)	Human methylation 27 DNA analysis bead-chip
2	2014	24306662		45	45	Y (120), N (34)	HBV (149), HCV (1), nonviral (4)	Illumina GoldenGate Methylation Beadarray Cancer Panel I
3	2014	25376292		22	22	N/A	HBV (1), HCV (9), alcohol (4), other (8)	Infinium Humanmethylation 27 Beadchip
4	2015	25945129	GSE59260	8	8	N/A	HBV-HCV-(8)	Nimblegen Human DNA Methylation 3 x 720K CpG Island PI
5	2011	21747116	GSE29720	12	12	N/A	N/A	Agilent-017075 human hg 18 promoter 800-200
6	2010	20165882	GSE18081	20	20	Y (20)	HCV (20)	Illumina Golden Gate Methylation Beadarray Cancer Panel I
7	2012	22234943	GSE37988	62	62	N/A	HBV-HCV-(7), HBV + HCV-(36), HBV-HCV+(6), HBV + HCV+(13)	Illumina Human Methylation27 Beadchip
8	2013	24012984	GSE44970	20	8	N/A	HCV (8)	Human Methylation27 Beadchip
9	2013	23208076	GSE54503	66	66	Y (48), N (17), missing (1)	HBV-HCV-(19), HCV (19), HBV (13), HBV + HCV (4), missing (11)	Infinium Human Methylation 450K Beadchip
10	2014	25093504	GSE57956	59	59	Y (37), N (21)	HBV+(36), HBV-(23)	Intinium Ilumanmethylation27 Beadchip
11	2014	25294808	GSE60753	27	27	Y (26), N (1)	HBV (1), HCV (7), alcohol (9), other (10)	Iinfinium -450K Human Methy lation Beadchip