Wnt-/-β-catenin pathway signaling in human hepatocellular carcinoma

Figure 1 Wnt-/-β-catenin signaling pathway. A: APC protein, axin, and GSK-3 that forms the complex destruction of the β-catenin protein in the proteasome; B: Wnt binds to Frizzled and LRP receptors, dissolving the destruction-complex, which results in an increase of β-catenin in the cytoplasm and nucleus. β-catenin forms a binding complex with the transcription factor LEF-/-TCF proteins to promote the activation of target genes. LRP: Lipoprotein receptor; Dvl: Dishevelled; APC: Adenomatous polyposis coli; GSK3: Glycogen synthase kinase 3; LET/TCF: Lymphoid enhancer factor/T-cell factor.