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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Three-dimensional cell culture systems as an in vitro platform for cancer and stem cell modeling  
Nipha Chaicharoenaudomrung, Phongsakorn Kunhorm, Parinya Noisa 
World J Stem Cells 11(12):1065-1083. Published online Dec 26, 2019. doi: 10.4252/wjsc.v11.i12.1065
2
Mesenchymal stem cells: Emerging mechanisms of immunomodulation and therapy  
Justin D Glenn, Katharine A Whartenby 
World J Stem Cells 6(5):526-539. Published online Nov 26, 2014. doi: 10.4252/wjsc.v6.i5.526
3
Secretion of immunoregulatory cytokines by mesenchymal stem cells  
Dobroslav Kyurkchiev, Ivan Bochev, Ekaterina Ivanova-Todorova, Milena Mourdjeva, Tsvetelina Oreshkova, Kalina Belemezova, Stanimir Kyurkchiev 
World J Stem Cells 6(5):552-570. Published online Nov 26, 2014. doi: 10.4252/wjsc.v6.i5.552
4
Distinction of white, beige and brown adipocytes derived from mesenchymal stem cells  
Anna Park, Won Kon Kim, Kwang-Hee Bae 
World J Stem Cells 6(1):33-42. Published online Jan 26, 2014. doi: 10.4252/wjsc.v6.i1.33
5
Mucosal-associated invariant T cells from induced pluripotent stem cells: A novel approach for modeling human diseases  
Chie Sugimoto, Hiroyoshi Fujita, Hiroshi Wakao 
World J Stem Cells 8(4):158-169. Published online Apr 26, 2016. doi: 10.4252/wjsc.v8.i4.158
6
Regenerative potential of mouse embryonic stem cell-derived PDGFRα+ cardiac lineage committed cells in infarcted myocardium  
Seon Pyo Hong, Sukhyun Song, Seungjoo Lee, Hyeonju Jo, Hyoung Kyu Kim, Jin Han, Jae-Hyeong Park, Sung Woo Cho 
World J Stem Cells 11(1):44-54. Published online Jan 26, 2019. doi: 10.4252/wjsc.v11.i1.44
7
Homing and migration of mesenchymal stromal cells: How to improve the efficacy of cell therapy?  
Ann De Becker, Ivan Van Riet 
World J Stem Cells 8(3):73-87. Published online Mar 26, 2016. doi: 10.4252/wjsc.v8.i3.73
8
Molecular mechanisms of mesenchymal stem cell differentiation towards osteoblasts  
Maya Fakhry, Eva Hamade, Bassam Badran, René Buchet, David Magne 
World J Stem Cells 5(4):136-148. Published online Oct 26, 2013. doi: 10.4252/wjsc.v5.i4.136
9
Umbilical cord-derived mesenchymal stem cells: Their advantages and potential clinical utility  
Tokiko Nagamura-Inoue, Haiping He 
World J Stem Cells 6(2):195-202. Published online Apr 26, 2014. doi: 10.4252/wjsc.v6.i2.195
10
Human umbilical cord mesenchymal stem cells ameliorate liver fibrosis in vitro and in vivo: From biological characteristics to therapeutic mechanisms  
Fei Yin, Wen-Ying Wang, Wen-Hua Jiang 
World J Stem Cells 11(8):548-564. Published online Aug 26, 2019. doi: 10.4252/wjsc.v11.i8.548
11
Epidermal stem cells and skin tissue engineering in hair follicle regeneration  
María Eugenia Balañá, Hernán Eduardo Charreau, Gustavo José Leirós 
World J Stem Cells 7(4):711-727. Published online May 26, 2015. doi: 10.4252/wjsc.v7.i4.711
12
Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment  
Antonin Bukovsky 
World J Stem Cells 8(12):399-427. Published online Dec 26, 2016. doi: 10.4252/wjsc.v8.i12.399
13
High frequency of CD34+CD38-/low immature leukemia cells is correlated with unfavorable prognosis in acute myeloid leukemia  
Adriana Plesa, Charles Dumontet, Eve Mattei, Ines Tagoug, Sandrine Hayette, Pierre Sujobert, Isabelle Tigaud, Marie Pierre Pages, Youcef Chelghoum, Fiorenza Baracco, Helene Labussierre, Sophie Ducastelle, Etienne Paubelle, Franck Emmanuel Nicolini, Mohamed Elhamri, Lydia Campos, Claudiu Plesa, Stéphane Morisset, Gilles Salles, Yves Bertrand, Mauricette Michallet, Xavier Thomas 
World J Stem Cells 9(12):227-234. Published online Dec 26, 2017. doi: 10.4252/wjsc.v9.i12.227
14
15
Role of Hox genes in stem cell differentiation  
Anne Seifert, David F Werheid, Silvana M Knapp, Edda Tobiasch 
World J Stem Cells 7(3):583-595. Published online Apr 26, 2015. doi: 10.4252/wjsc.v7.i3.583
16
Current progress in use of adipose derived stem cells in peripheral nerve regeneration  
Shomari DL Zack-Williams, Peter E Butler, Deepak M Kalaskar 
World J Stem Cells 7(1):51-64. Published online Jan 26, 2015. doi: 10.4252/wjsc.v7.i1.51
17
Common stemness regulators of embryonic and cancer stem cells  
Christiana Hadjimichael, Konstantina Chanoumidou, Natalia Papadopoulou, Panagiota Arampatzi, Joseph Papamatheakis, Androniki Kretsovali 
World J Stem Cells 7(9):1150-1184. Published online Oct 26, 2015. doi: 10.4252/wjsc.v7.i9.1150
18
Endometrial mesenchymal stem cells as a cell based therapy for pelvic organ prolapse  
Stuart J Emmerson, Caroline E Gargett 
World J Stem Cells 8(5):202-215. Published online May 26, 2016. doi: 10.4252/wjsc.v8.i5.202
19
Augmenting peripheral nerve regeneration using stem cells: A review of current opinion  
Neil G Fairbairn, Amanda M Meppelink, Joanna Ng-Glazier, Mark A Randolph, Jonathan M Winograd 
World J Stem Cells 7(1):11-26. Published online Jan 26, 2015. doi: 10.4252/wjsc.v7.i1.11
20
Cancer stem cell impact on clinical oncology  
Mariel E Toledo-Guzmán, Gabriele D Bigoni-Ordóñez, Miguel Ibáñez Hernández, Elizabeth Ortiz-Sánchez 
World J Stem Cells 10(12):183-195. Published online Dec 26, 2018. doi: 10.4252/wjsc.v10.i12.183
21
Human dental pulp stem cells: Applications in future regenerative medicine  
Pravin D Potdar, Yogita D Jethmalani 
World J Stem Cells 7(5):839-851. Published online Jun 26, 2015. doi: 10.4252/wjsc.v7.i5.839
22
Rat model of anal sphincter injury and two approaches for stem cell administration  
Jacobo Trébol, Tihomir Georgiev-Hristov, Luz Vega-Clemente, Ignacio García-Gómez, Ana Carabias-Orgaz, Mariano García-Arranz, Damián García-Olmo 
World J Stem Cells 10(1):1-14. Published online Jan 26, 2018. doi: 10.4252/wjsc.v10.i1.1
23
Application of mesenchymal stem cell therapy for the treatment of osteoarthritis of the knee: A concise review  
Ai-Tong Wang, Ying Feng, Hong-Hong Jia, Meng Zhao, Hao Yu 
World J Stem Cells 11(4):222-235. Published online Apr 26, 2019. doi: 10.4252/wjsc.v11.i4.222
24
Sox2, a key factor in the regulation of pluripotency and neural differentiation  
Shuchen Zhang, Wei Cui 
World J Stem Cells 6(3):305-311. Published online Jul 26, 2014. doi: 10.4252/wjsc.v6.i3.305
25
Human induced pluripotent stem cells for monogenic disease modelling and therapy  
Paola Spitalieri, Valentina Rosa Talarico, Michela Murdocca, Giuseppe Novelli, Federica Sangiuolo 
World J Stem Cells 8(4):118-135. Published online Apr 26, 2016. doi: 10.4252/wjsc.v8.i4.118
26
Similarities and differences between mesenchymal stem/progenitor cells derived from various human tissues  
Urszula Kozlowska, Agnieszka Krawczenko, Katarzyna Futoma, Tomasz Jurek, Marta Rorat, Dariusz Patrzalek, Aleksandra Klimczak 
World J Stem Cells 11(6):347-374. Published online Jun 26, 2019. doi: 10.4252/wjsc.v11.i6.347
27
Targeting cancer stem cells in drug discovery: Current state and future perspectives  
Fang-Yu Du, Qi-Fan Zhou, Wen-Jiao Sun, Guo-Liang Chen 
World J Stem Cells 11(7):398-420. Published online Jul 26, 2019. doi: 10.4252/wjsc.v11.i7.398
28
Next-generation sequencing traces human induced pluripotent stem cell lines clonally generated from heterogeneous cancer tissue  
Tetsuya Ishikawa 
World J Stem Cells 9(5):77-88. Published online May 26, 2017. doi: 10.4252/wjsc.v9.i5.77
29
Immunomodulation by mesenchymal stem cells: Interplay between mesenchymal stem cells and regulatory lymphocytes  
Oscar Ka-Fai Ma, Koon Ho Chan 
World J Stem Cells 8(9):268-278. Published online Sep 26, 2016. doi: 10.4252/wjsc.v8.i9.268
30
Rational use of mesenchymal stem cells in the treatment of autism spectrum disorders  
Qiang Liu, Mo-Xian Chen, Lin Sun, Chloe U Wallis, Jian-Song Zhou, Li-Juan Ao, Qi Li, Pak C Sham 
World J Stem Cells 11(2):55-72. Published online Feb 26, 2019. doi: 10.4252/wjsc.v11.i2.55
31
Migration of bone marrow progenitor cells in the adult brain of rats and rabbits  
Donnahue Dennie, Jean-Pierre Louboutin, David S Strayer 
World J Stem Cells 8(4):136-157. Published online Apr 26, 2016. doi: 10.4252/wjsc.v8.i4.136
32
Triple-modal imaging of stem-cells labeled with multimodal nanoparticles, applied in a stroke model  
Helio Rodrigues da Silva, Javier Bustamante Mamani, Mariana Penteado Nucci, Leopoldo Penteado Nucci, Andrea Tiemi Kondo, Daianne Maciely Carvalho Fantacini, Lucas Eduardo Botelho de Souza, Virginia Picanço-Castro, Dimas Tadeu Covas, José Mauro Kutner, Fernando Anselmo de Oliveira, Nelson Hamerschlak, Lionel Fernel Gamarra 
World J Stem Cells 11(2):100-123. Published online Feb 26, 2019. doi: 10.4252/wjsc.v11.i2.100
33
Stromal cell-derived factor-1α promotes recruitment and differentiation of nucleus pulposus-derived stem cells  
Jin-Wei Ying, Tian-Yong Wen, Shi-Shen Pei, Ling-Hao Su, Di-Ke Ruan 
World J Stem Cells 11(3):196-211. Published online Mar 26, 2019. doi: 10.4252/wjsc.v11.i3.196
34
Current methods for the maturation of induced pluripotent stem cell-derived cardiomyocytes  
Pranav Machiraju, Steven C Greenway 
World J Stem Cells 11(1):33-43. Published online Jan 26, 2019. doi: 10.4252/wjsc.v11.i1.33
35
Issues and opportunities of stem cell therapy in autoimmune diseases  
Györgyi Műzes, Ferenc Sipos 
World J Stem Cells 11(4):212-221. Published online Apr 26, 2019. doi: 10.4252/wjsc.v11.i4.212
36
Adipose-derived stromal/stem cells from different adipose depots in obesity development  
Karina Ribeiro Silva, Leandra Santos Baptista 
World J Stem Cells 11(3):147-166. Published online Mar 26, 2019. doi: 10.4252/wjsc.v11.i3.147
37
Long non-coding RNA: The functional regulator of mesenchymal stem cells  
Zhong-Yu Xie, Peng Wang, Yan-Feng Wu, Hui-Yong Shen 
World J Stem Cells 11(3):167-179. Published online Mar 26, 2019. doi: 10.4252/wjsc.v11.i3.167
38
Inducing human induced pluripotent stem cell differentiation through embryoid bodies: A practical and stable approach  
Ning-Ning Guo, Li-Ping Liu, Yun-Wen Zheng, Yu-Mei Li 
World J Stem Cells 12(1):25-34. Published online Jan 26, 2020. doi: 10.4252/wjsc.v12.i1.25
39
Cancer stem cell plasticity and tumor hierarchy  
Marina Carla Cabrera, Robert E Hollingsworth, Elaine M Hurt 
World J Stem Cells 7(1):27-36. Published online Jan 26, 2015. doi: 10.4252/wjsc.v7.i1.27
40
Applications of stem cells and bioprinting for potential treatment of diabetes  
Shweta Anil Kumar, Monica Delgado, Victor E Mendez, Binata Joddar 
World J Stem Cells 11(1):13-32. Published online Jan 26, 2019. doi: 10.4252/wjsc.v11.i1.13
41
Renal progenitors: Roles in kidney disease and regeneration  
Brooke E Chambers, Rebecca A Wingert 
World J Stem Cells 8(11):367-375. Published online Nov 26, 2016. doi: 10.4252/wjsc.v8.i11.367
42
Functional and molecular mechanism of intracellular pH regulation in human inducible pluripotent stem cells  
Shih-Chi Chao, Gwo-Jang Wu, Shu-Fu Huang, Niann-Tzyy Dai, Hsu-Kai Huang, Mei-Fang Chou, Yi-Ting Tsai, Shiao-Pieng Lee, Shih-Hurng Loh 
World J Stem Cells 10(12):196-211. Published online Dec 26, 2018. doi: 10.4252/wjsc.v10.i12.196
43
Immunomodulatory oligonucleotide IMT504: Effects on mesenchymal stem cells as a first-in-class immunoprotective/immunoregenerative therapy  
Jorge Zorzopulos, Steven M Opal, Andrés Hernando-Insúa, Juan M Rodriguez, Fernanda Elías, Juan Fló, Ricardo A López, Norma A Chasseing, Victoria A Lux-Lantos, Maria F Coronel, Raul Franco, Alejandro D Montaner, David L Horn 
World J Stem Cells 9(3):45-67. Published online Mar 26, 2017. doi: 10.4252/wjsc.v9.i3.45
44
Regeneration of the central nervous system-principles from brain regeneration in adult zebrafish  
Alessandro Zambusi, Jovica Ninkovic 
World J Stem Cells 12(1):8-24. Published online Jan 26, 2020. doi: 10.4252/wjsc.v12.i1.8
45
Early B lymphocyte development: Similarities and differences in human and mouse  
Michiko Ichii, Kenji Oritani, Yuzuru Kanakura 
World J Stem Cells 6(4):421-431. Published online Sep 26, 2014. doi: 10.4252/wjsc.v6.i4.421
46
Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment  
Ying Xiong, Lindsay T McDonald, Dayvia L Russell, Ryan R Kelly, Katie R Wilson, Meenal Mehrotra, Adam C Soloff, Amanda C LaRue 
World J Stem Cells 7(2):253-265. Published online Mar 26, 2015. doi: 10.4252/wjsc.v7.i2.253
47
Tracing and targeting cancer stem cells: New venture for personalized molecular cancer therapy  
Ramin Radpour 
World J Stem Cells 9(10):169-178. Published online Oct 26, 2017. doi: 10.4252/wjsc.v9.i10.169
48
Neural stem cell transplantation therapy for brain ischemic stroke: Review and perspectives  
Gui-Long Zhang, Zhi-Han Zhu, Ye-Zhong Wang 
World J Stem Cells 11(10):817-830. Published online Oct 26, 2019. doi: 10.4252/wjsc.v11.i10.817
49
Regulation of mitochondrial function and endoplasmic reticulum stress by nitric oxide in pluripotent stem cells  
Estefania Caballano-Infantes, José Terron-Bautista, Amparo Beltrán-Povea, Gladys M Cahuana, Bernat Soria, Hajji Nabil, Francisco J Bedoya, Juan R Tejedo 
World J Stem Cells 9(2):26-36. Published online Feb 26, 2017. doi: 10.4252/wjsc.v9.i2.26
50
Stem cell-derived exosomes as a therapeutic tool for cardiovascular disease  
Etsu Suzuki, Daishi Fujita, Masao Takahashi, Shigeyoshi Oba, Hiroaki Nishimatsu 
World J Stem Cells 8(9):297-305. Published online Sep 26, 2016. doi: 10.4252/wjsc.v8.i9.297