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Copyright ©The Author(s) 2016.
World J Stem Cells. Sep 26, 2016; 8(9): 297-305
Published online Sep 26, 2016. doi: 10.4252/wjsc.v8.i9.297
Table 1 Effects of exosome administration on cardiovascular disease models
Origin of exosomesExperimental modelFindingsRef.
Human ESC-derived MSCsAMIReduction in infarct size Recovery of cardiac function Decreased oxidative stress Activation of Akt and GSK3 Inhibition of c-JNKLai et al[52,53]
Human MSCsAMIReduction in infarct size Recovery of cardiac function Increased angiogenesisBian et al[54]
Mouse MSCsAMIExosomes were enriched in miR-22 miR22 was implicated in the anti-apoptotic effect of exosomesFeng et al[55]
Rat MSCs overexpressing GATA-4AMIReduction in infarct size Recovery of cardiac function Exosomes were enriched in miR-19aYu et al[56]
Rat MSCsStrokeRecovery of neurological function Stimulation of neurogenesis and angiogenesisXin et al[57]
Rat MSCs overexpressing miR-133b and those whose expression of miR-133b was knocked downStrokeRecovery of neurological function was mediated by miR-133b expressed in exosomesXin et al[58]
Mouse MSCsPulmonary hypertensionReduction in the progression of pulmonary hypertension and right ventricular hypertrophyLee et al[59]
Mouse CPCsAMISuppression of apoptosisChen et al[60]
Human CPCsAMIRecovery of cardiac function Suppression of apoptosis Stimulation of angiogenesisBarile et al[61]
Human CPCsAMIRecovery of cardiac function Suppression of apoptosis Stimulation of angiogenesis miR-146a was enriched in exosomes and partially mediated their functionIbrahim et al[62]
Mouse ESCsAMIRecovery of cardiac function Stimulation of angiogenesis and cardiomyocyte survival Stimulation of the survival and proliferation of CPCs miR-294 was enriched in exosomes and miR-294 promoted the survival and proliferation of CPCsKhan et al[63]
Human CD34+ cellsMatrigel plug assay Corneal angiogenesis assayPromotion of angiogenesisSahoo et al[64]
Human CD34+ cells expressing SHHAMIRecovery of cardiac function SHH was enriched in exosomes and transferred to recipient cellsMackie et al[66]