Copyright
©The Author(s) 2016.
World J Stem Cells. Sep 26, 2016; 8(9): 297-305
Published online Sep 26, 2016. doi: 10.4252/wjsc.v8.i9.297
Published online Sep 26, 2016. doi: 10.4252/wjsc.v8.i9.297
Origin of exosomes | Experimental model | Findings | Ref. |
Human ESC-derived MSCs | AMI | Reduction in infarct size Recovery of cardiac function Decreased oxidative stress Activation of Akt and GSK3 Inhibition of c-JNK | Lai et al[52,53] |
Human MSCs | AMI | Reduction in infarct size Recovery of cardiac function Increased angiogenesis | Bian et al[54] |
Mouse MSCs | AMI | Exosomes were enriched in miR-22 miR22 was implicated in the anti-apoptotic effect of exosomes | Feng et al[55] |
Rat MSCs overexpressing GATA-4 | AMI | Reduction in infarct size Recovery of cardiac function Exosomes were enriched in miR-19a | Yu et al[56] |
Rat MSCs | Stroke | Recovery of neurological function Stimulation of neurogenesis and angiogenesis | Xin et al[57] |
Rat MSCs overexpressing miR-133b and those whose expression of miR-133b was knocked down | Stroke | Recovery of neurological function was mediated by miR-133b expressed in exosomes | Xin et al[58] |
Mouse MSCs | Pulmonary hypertension | Reduction in the progression of pulmonary hypertension and right ventricular hypertrophy | Lee et al[59] |
Mouse CPCs | AMI | Suppression of apoptosis | Chen et al[60] |
Human CPCs | AMI | Recovery of cardiac function Suppression of apoptosis Stimulation of angiogenesis | Barile et al[61] |
Human CPCs | AMI | Recovery of cardiac function Suppression of apoptosis Stimulation of angiogenesis miR-146a was enriched in exosomes and partially mediated their function | Ibrahim et al[62] |
Mouse ESCs | AMI | Recovery of cardiac function Stimulation of angiogenesis and cardiomyocyte survival Stimulation of the survival and proliferation of CPCs miR-294 was enriched in exosomes and miR-294 promoted the survival and proliferation of CPCs | Khan et al[63] |
Human CD34+ cells | Matrigel plug assay Corneal angiogenesis assay | Promotion of angiogenesis | Sahoo et al[64] |
Human CD34+ cells expressing SHH | AMI | Recovery of cardiac function SHH was enriched in exosomes and transferred to recipient cells | Mackie et al[66] |
- Citation: Suzuki E, Fujita D, Takahashi M, Oba S, Nishimatsu H. Stem cell-derived exosomes as a therapeutic tool for cardiovascular disease. World J Stem Cells 2016; 8(9): 297-305
- URL: https://www.wjgnet.com/1948-0210/full/v8/i9/297.htm
- DOI: https://dx.doi.org/10.4252/wjsc.v8.i9.297