Endometrial mesenchymal stem cells as a cell based therapy for pelvic organ prolapse

Figure 7 Human e-mesenchymal stem cells improves the biocompatibility of polyamide/gelatin (PA + G) mesh in a fascial wound defect in nude rats. PA + G mesh seeded with 100000 eMSC/cm² and cultured for 48 h, prior to implantation (A); Physiological crimped collagen deposited around eMSC⁺/PA + G mesh (B); Scar-like collagen in PA + G mesh alone as observed by SEM (C); Load-elongation curves of explanted meshes with (red) and without (blue) eMSC showing less stiffness (slope) and longer toe region for mesh seeded with eMSC, indicating improved biomechanical properties (reproduced from ref.[57,86,89] with permission) (D). MSC: Mesenchymal stem cells; PA : Polyamide; G: Gelatin.