Endometrial mesenchymal stem cells as a cell based therapy for pelvic organ prolapse

Figure 4 Specific enriching for endometrial mesenchymal stem cells. Flow cytometry plot of CD146⁺PDGFRB⁺ fraction (A) which contains most of the clonogenic stromal cells (B) and reveals their pericyte identity in vivo (C); SUSD2⁺ cells in endometrial cell suspensions (D) which E reconstitute human vimentin+ stromal tissue when transplanted under the kidney capsule of NSG mice, and F have a perivascular location in human endometrium. SUSD2⁺ cells (red) do not express estrogen receptor-α (green), but endometrial stromal cells do (DNA blue). The white arrow indicates perivascular SUSD2⁺ cells (reproduced ref. [70,72,78] with permission).