Mucosal-associated invariant T cells from induced pluripotent stem cells: A novel approach for modeling human diseases

Figure 1 Comparison of the T cell receptors and the antigen presenting molecules among αβ T cell subsets. Invariant T cell subsets consist of mucosal-associated invariant T (MAIT) cells and natural killer T (NKT) cells expressing invariant TCRs. MAIT cells and NKT cells recognize vitamin B2 metabolites on MR1, and α-galactosylceramide (α-GalCer) on CD1d, respectively. In contrast, conventional CD8⁺ and CD4⁺ T cells possess divergent TCRs and recognize a variety of peptides on major histocompatibility complex-class I and class II, respectively. TCRs: T cell receptors; MHC: Major histocompatibility complex.