Homing and migration of mesenchymal stromal cells: How to improve the efficacy of cell therapy?

Figure 2 Schematic overview of the different strategies that can be used to improve homing in the different steps of mesenchymal stromal cell migration. CD: Cluster of differentiation; EC: Endothelial cell; BM: Basement membrane; HCELL: Hematopoietic cell E-/L-selectin ligand; PSGL-1: P-selectin glycoprotein ligand-1; SLEX: Sialyl Lewis X; SDF-1: Stromal cell derived factor 1; VLA-4: Very late antigen 4; VCAM-1: Vascular cell adhesion molecule 1; Ab: Antibody; TIMP: Tissue inhibitor of metalloproteinases; MMP: Matrix metalloproteinase; EPO: Erythropoietin; G-CSF: Granulocyte colony stimulating factor; MSC: Mesenchymal stromal cell.