Updates in the pathophysiological mechanisms of Parkinson&rsquo;s disease: Emerging role of bone marrow mesenchymal stem cells

doi:10.4252/wjsc.v8.i3.106

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Mar 26, 2016; 8(3): 106-117
Published online Mar 26, 2016. doi: 10.4252/wjsc.v8.i3.106

Table 1 Effect of treatment with bone marrow derived mesenchymal stem cells on serum transforming growth factor beta-1 and monocyte chemoattractant protein-1 levels in Parkinson’s disease model

	TGF-β1 (pg/mL)	MCP-1 (pg/mL)
Ovariectomized control	481.5 ± 7.5	88.1 ± 0.9
PD untreated	691.2 ± 8.0^a	112.1 ± 1.9^a
PD + BM-MSCs	489.7 ± 13.0^c	89.6 ± 2.0^c

Data are represented as mean ± SE of 8 rats/group.

^aSignificant change at P < 0.05 in comparison with the ovariectomized control group;

^cSignificant change at P < 0.05 in comparison with the untreated PD group. PD: Parkinson’s disease; BM-MSCs: Bone marrow derived mesenchymal stem cells; TGF-β1: Transforming growth factor beta-1; MCP-1: Monocyte chemoattractant protein-1.

Citation: Ahmed HH, Salem AM, Atta HM, Eskandar EF, Farrag ARH, Ghazy MA, Salem NA, Aglan HA. Updates in the pathophysiological mechanisms of Parkinson’s disease: Emerging role of bone marrow mesenchymal stem cells. World J Stem Cells 2016; 8(3): 106-117
URL: https://www.wjgnet.com/1948-0210/full/v8/i3/106.htm
DOI: https://dx.doi.org/10.4252/wjsc.v8.i3.106