Generation of diverse neural cell types through direct conversion

doi:10.4252/wjsc.v8.i2.32

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Feb 26, 2016; 8(2): 32-46
Published online Feb 26, 2016. doi: 10.4252/wjsc.v8.i2.32

Table 3 Summary of studies demonstrating generation of functional induced neural stem and progenitor cells by direct conversion

Species	Original cell	Transgenes	Method	End cell	Ref.
Mouse	Fibroblast	OSKM	iLV	iNPC	[101]
Human	Melanocyte	Notch1	LV	iNCC	[102]
Human	Astrocyte	4-Oct	LV	iNSC	[110]
Human	Astrocyte	Sox2	LV	iNSC	[110]
Human	Astrocyte	Nanog	LV	iNSC	[110]
Mouse	Fibroblast	Brn4, Sox2, Klf4, c-Myc, E47	RV	iNSC	[105]
Human	Fibroblast	Oct4, Sox2, Klf4, Zic3	RV	iNPC	[104]
Mouse	Fibroblast	Brn2, Sox2, FoxG1	iLV	iNPC	[123]
Mouse	Fibroblast	OSKM	RV	iNSC	[116]
Human	Fibroblast	OSKM	RV	iNSC	[116]
Human	Fibroblast	Sox2, Pax6	NV	iNPC	[98]
Mouse	Fibroblast	Sox2	RV	iNSC	[122]
Human	Fibroblast	Sox2	RV	iNSC	[122]
Mouse	Sertoli cell	Ascl1, Ngn2, Hes1, Id1, Pax6, Brn2, Sox2, c-Myc, Klf4	RV	iNSC	[111]
Mouse	Fibroblast	OSKM	RV/iLV	iNSC	[117]
Mouse	Fibroblast	Brn2, Nr2e1, Sox2, c-Myc, Bmi1	RV	iNPC	[157]
Human	Fibroblast	OSKM	SV	iNPC	[118]
Monkey	Fibroblast	OSKM	SV	iNPC	[118]
Mouse	Fibroblast	Sox10, Olig2, Nkx6.2	LV	iOPC	[107]
Human	Urine cells	Oct4, Sox2, Klf4, SV40LT, miR-302-367	NV	iNPC	[112]
Mouse	Fibroblast	Sox10, Olig2, Zfp536	iLV	iOPC	[108]
Rat	Fibroblast	Sox10, Olig2, Zfp536	iLV	iOPC	[108]
Human	Fibroblast	Oct3, Sox2, Klf4, c-Myc	RV	iNPC	[125]
Mouse	Fibroblasts	Brn2, Hes1, Hes3, Klf4, c-Myc, Plagl1, Notch1 (NICD), Rfx4	NV	iNSC	[99]
Mouse	Liver cells	Brn2, Hes1, Hes3, Klf4, c-Myc, Plagl1, Notch1 (NICD), Rfx4	NV	iNSC	[99]
Mouse	Blymphocytes	Brn2, Hes1, Hes3, Klf4, c-Myc, Plagl1, Notch1 (NICD), Rfx4	NV	iNSC	[99]
Mouse	Fibroblast	OSKM	iLV	iDNPC	[109]
Rat	Bone marrow-derived stem cell	Ngn2	LV	iNPC	[114]
Mouse	Fibroblast	Sox2, Klf4, c-Myc, Brn4	RV	iNSC	[158]
Human	Fibroblast	Sox10	iLV	iNCC	[103]
Human	Fibroblast	4-Oct	LV	iNPC	[121]
Pig	Fibroblast	Oct4, Sox2, Klf4, Lin28, L-Myc	NV	iNPC	[120]
Human	Fibroblast	4-Oct	LV	iNSC	[119]
Human	Fibroblast	Oct4, Sox2, Klf4, shR-p53	NV	iNSC	[119]
Human	Fibroblast	Sox2, c-Myc, Brn2	LV	iNPC	[159]
Human	Fibroblast	Sox2, c-Myc, Brn4	LV	iNPC	[159]
Human	Astrocyte	miR-302/367	LV	iNB	[106]
Human	Fibroblast	Sox2, HMGA2	RV	iNSC	[113]
Human	Cord blood-derived stem cell	Sox2, HMGA2	RV	iNSC	[113]

OSKM: Oct4, Sox2, Klf4, c-Myc; miR: MicroRNA; shR: Small hairpin RNA; NICD: Notch intracellular domain; HMGA2: High-mobility group A2; iLV: Inducible lentiviral vector; LV: Lentiviral vector; RV: Retroviral vector; SV: Sendai virus vector; NV: Non-viral; iNCC: Induced neural crest cell; iNSC: Induced neural stem cell; iNPC: Induced neural progenitor cell; iOPC: Induced oligodendrocyte progenitor cell; iDNPC: Induced dopaminergic neuronal progenitor cell; iNB: Induced neuroblast.

Citation: Petersen GF, Strappe PM. Generation of diverse neural cell types through direct conversion. World J Stem Cells 2016; 8(2): 32-46
URL: https://www.wjgnet.com/1948-0210/full/v8/i2/32.htm
DOI: https://dx.doi.org/10.4252/wjsc.v8.i2.32