Renal progenitors: Roles in kidney disease and regeneration

Figure 5 Neonephrogenesis in the adult zebrafish. Adult zebrafish possess the unique ability to generate new nephrons during adulthood. Neonephrogenesis in zebrafish mimics the cellular dynamics of nephrogenesis during mammalian kidney development. Renal progenitors cluster to create a PTA. This aggregate changes morphology as it first forms a comma-shape followed by an S-shape. The SSB differentiates into specific cell types that comprise the blood filter and tubules of a mature nephron. CD: Collecting duct; G: Glomerulus; PTA: Pre-tubular aggregate; CSB: Comma-shaped body; SSB: S-shaped body.