Renal progenitors: Roles in kidney disease and regeneration

Figure 1 The progression of kidney organogenesis in mammals. The MM is derived from the IM. The MM condenses to form the CM, a renal progenitor population. These progenitors receive signals to self renew (dark green) or differentiate (light green). Cells receiving differentiation signals are organized into an epithelialized RV. Upon further maturation, these cells form a CSB, then an SSB, and finally the N. IM: Intermediate mesoderm; MM: Metanephric mesenchyme; UB: Ureteric bud; CM: Cap mesenchyme; RV: Renal vesicle; CSB: Comma-shaped body; SSB: S-shaped body; N: Nephron; CD: Collecting duct.