Stem/progenitor cells and obstructive sleep apnea syndrome - new insights for clinical applications

Table 3 Circulating endothelial progenitor cells studies in patients with obstructive sleep apnea syndrome treated by continuous positive airway pressure

Ref.	Study design	EPCs phenotype	CPAP effect on EPCs number
Jelic et al[61]	Adults, both genders, flow cytometry	CD34+CD133+VEGFR2+	Normalized after 4 wk of CPAP
Jelic et al[62]	Adults, both genders, flow cytometry	CD34+CD133+VEGFR2+	Normalized after 4 wk of CPAP
Murri et al[63]	Adults, both genders, flow cytometry	CD45-CD34+CD133+VEGFR2+	Values returned to control values after 1 mo of CPAP
Simpson et al[67]	Adults, men, flow cytometry	CD34+KDR+ CD34+KDR+CD45-	Unchanged
Kizawa et al[68]	Adults, men, flow cytometry	CD133+CD34+CD202b+CD45-	Values decreased after 12 wk of CPAP treatment
Chou et al[70]	Adults, both genders, flow cytometry	CD34+	Mobilization ratio in patients with OSAS tended to decline

EPC: Endothelial progenitor cell; OSAS: Obstructive sleep apnea syndrome; CPAP: Continuous positive airway pressure.