Targeting head and neck tumoral stem cells: From biological aspects to therapeutic perspectives

doi:10.4252/wjsc.v8.i1.13

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Jan 26, 2016 (publication date) through Jul 24, 2024

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Jan 26, 2016; 8(1): 13-21
Published online Jan 26, 2016. doi: 10.4252/wjsc.v8.i1.13

Table 2 Main determinants of cancer stem cell radioresistance

Molecular determinants of radioresistance	Mechanism
Intrinsic determinants	Enhanced DNA repair capability
	Protection from oxidative DNA damage
	Activation of the cell survival pathways
	(PI3K/Akt, WNT/β-catenin, notch)
	Expression of drug efflux pumps
Extrinsic determinants	Hypoxic environment

Citation: Méry B, Guy JB, Espenel S, Wozny AS, Simonet S, Vallard A, Alphonse G, Ardail D, Rodriguez-Lafrasse C, Magné N. Targeting head and neck tumoral stem cells: From biological aspects to therapeutic perspectives. World J Stem Cells 2016; 8(1): 13-21
URL: https://www.wjgnet.com/1948-0210/full/v8/i1/13.htm
DOI: https://dx.doi.org/10.4252/wjsc.v8.i1.13