Allogenic banking of dental pulp stem cells for innovative therapeutics

Figure 2 Process flowchart for current Good Manufacturing Practices manufacturing of dental pulp stem cell lots/therapeutic products. The chart is divided into 4 areas: Hospital for tooth recovery, Cell Bank, Research Institute and Hospital for clinical applications: (1) Hospital: direct contact between patients and authorized medical staff, such as Medical Doctor (MD) or Doctor of Dental Surgery (DDS). Clinical sample and donor’s personal data are recovered; (2) Cell Bank: current Good Manufacturing Practices manufacturing of Advanced Therapy Medicinal Products (ATMP) from the biological samples (dental pulps). All data concerning the donors are anonymous; (3) Research Institute: dental pulp stem cell (DPSC) lots are used for animal experiments to develop new therapeutics; and (4) Hospital: clinical grade DPSC lots are used for therapeutics. Red arrows represent critical parameters related to each step of processing (informed consent, quality, safety, confidentiality). HLA: Human leukocyte antigen.