Role of Hox genes in stem cell differentiation

doi:10.4252/wjsc.v7.i3.583

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Apr 26, 2015; 7(3): 583-595
Published online Apr 26, 2015. doi: 10.4252/wjsc.v7.i3.583

Table 1 Hox gene expression in various kinds of stem cells

Type of stem cell	Hox expression	Role of Hox
HSC	HOXA cluster	Hematopoiesis and its transition from embryonic to adult program
HSC	HOXB4
MSC	HOXA5, 10	Degree of Hox expression pattern differs in the different sources and determines differentiation potential
	HOXB6, 7
	HOXC4, 6, 8, 9, 10
	HOXD3 and D8
ESC	None	Active repression of Hox genes until commitment starts
CSC	Various	Overexpression of Hox genes present in undifferentiated cells and down-regulation Hox genes present in differentiated cells
	HOXA9	Hematopoiesis
	HOXB7, C6, C8	Vascularization
	HOXA4, D10	Colon carcinoma
NCC	HOXD3	Formation of somitic mesoderm- and neural crest-derived structures
iPS	None	Active repression of Hox genes until commitment starts

HSC: Hematopoietic stem cells; MSC: Mesenchymal stem cells; ESC: Embryonic stem cells; CSC: Cancer stem cells; NCC: Neural crest cells; iPS: Induced pluripotent stem cells.

Citation: Seifert A, Werheid DF, Knapp SM, Tobiasch E. Role of Hox genes in stem cell differentiation. World J Stem Cells 2015; 7(3): 583-595
URL: https://www.wjgnet.com/1948-0210/full/v7/i3/583.htm
DOI: https://dx.doi.org/10.4252/wjsc.v7.i3.583