Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment

Figure 3 Therapeutic implications. We hypothesize that the identification of pathways from the hematopoietic stem cell (HSC) to the cancer-associated adipocyte (CAA) and cancer-associated fibroblast (CAF) provides a potential opportunity to target these pro-tumorigenic cells both early in their differentiation and at multiple points in their maturation, which may lead to a more encompassing downstream inhibition of their contributions to tumor progression and metastasis.