Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment

Figure 1 Multifactorial contributions of cancer-associated adipocytes and cancer-associated fibroblasts to tumor progression and metastasis. Research in the last decade has highlighted the importance of the tumor microenvironment in cancer progression. While there are numerous stromal cell types that contribute to the tumor microenvironment, this illustration depicts roles for cancer-associated adipocytes (CAAs) and cancer-associated fibroblasts (CAFs) in promoting the multiple stages of tumor progression and metastasis. ECM: Extracellular matrix.