Stem cell therapy in inflammatory bowel disease: A promising therapeutic strategy?

Table 3 Mesenchymal stem cell transplantation studies in perianal Crohn's disease

Ref.	Patients (n)	Procedence	Follow up (mo)	SAEs related	Response/closure (number of patients or fistulas, time of evaluation	Recurrence (number of patients, time of evaluation in months)
García-Olmo et al[53]	4 patients (8 fistulas)	Adipose Autologous	22 mo (range 12-30)	No	2/6 (2 mo)	NA
García-Olmo et al[54]	49 (14 CD) 25 (7 CD) fibrin glue (group A) 24 (7CD) ASCs (group B)	Adipose Autologous	12 mo	No	Group A: NA/1 (7 CD) Group B: 2/5 (7 CD)	3/17 global recurrence in group B (12 mo) Data for CD NA
Ciccocioppo et al[55]	10	BM Autologous	12 mo	No	3/7 (12 mo)	0/7 (12 mo)
de la Portilla et al[56]	22 per protocol	Adipose Allogenic	6 mo	2 SAEs possibly related Pyerxia Abscess	Closure: 5/18 fistulas (6 mo)	NA
Cho et al[57]	10	Adipose Autologous	6 mo	No SAEs	1/3 (2 mo)	0/3 (8 mo)
Lee et al[58]	33 per protocol	Adipose Autologous	12 mo	No SAEs	5/27 (2 mo) Per protocol	3/26 (12 mo)

BM: Bone marrow; CD: Crohn´s disease; NA: Not available.