Review
Copyright ©The Author(s) 2015.
World J Stem Cells. Mar 26, 2015; 7(2): 329-342
Published online Mar 26, 2015. doi: 10.4252/wjsc.v7.i2.329
Table 2 Inherited cardiac diseases modeled using Induced pluripotent stem cell
Cardiac diseaseGeneProtein/currentChrMutationDifferentiation methodCardiomyocyte subtypeMaturation daysRef.
HCMMYH7Myosin heavy chain β14q12R663H3D spontaneous[19]
DCMLMNALamin A1q22R225XEND-2 co-cultureV- and A-like20[25]
GCCA insertion
TNNT2Troponin T type 21q32R173W3D, activin, BMP4, DKK1, FGF2, VEGFV-, A-, and N-like> 30[27]
DESDesmin2q35A285VEND co-culturen.d.> 14[26]
BTHSTAZTafazzinXq28517delG2D, activin, BMP4n.d.> 12[30]
c.328T>C
LQT1KCNQ1Kv7.1/I(Ks)11p15R190Q3D spontaneousV-, A-, and N-like20-30[36]
LQT2KCNH2hERG/I(Kr)7q36R176W3D spontaneousV- and A-liken.d.[42]
A561TV-, A-, and N-like25-30[38]
A561VV- and A-like21[45]
A614VV-, A-, and N-like> 30[37]
N996In.d.20-60[43]
LQT3SCN5ANav1.5 /I(Na)3p21F1473C3D, activin, BMP4, Wnt-I, FGF2V- and A-like25-45[50]
V1763M3D spontaneousV-, A-, and N-like> 28[51]
V240M, R535QEND-2 co-cultureV-, A-, and N-like20-30[52]
LQT8CACNA1CCaV1.2/I(Ca)12p13G1216A3D + Wnt3aV-, A-, and N-like> 37[55]
CPVTRYR2Ryanodine receptor 2/I(Ca)1q43F2483IEND-2 co-cultureV-, A-, and N-like20-30[61]
P2328SEND-2 co-cultureMostly V-liken.d.[62]
S406L3D spontaneousV-, A-, and N-like> 70[64]
M4109R3D spontaneousV-, A-, and N-like> 30[65]
E2311D3D spontaneousV/A- and N-like> 30[66]
CASQ2Calsequestrin1p13D307H3D spontaneousn.d.25-43[67]
ARVCPKP2Plakophilin-212p11L614P3D spontaneousV-, A-, and N-like> 28[72]
A324fs335X3D spontaneousn.d.> 30[73]
T50SfsX110
Criptic splicing3D spontaneousn.d.> 60[74]
c.2013delC