Induced pluripotent stem cells: Mechanisms, achievements and perspectives in farm animals

Table 2 Achievements with induced pluripotent stem cells from rodents, farm animals and humans

	Rodents	Farm animals	Human
iPS cells	√√	√√	√√
In vivo differentiation	√√	√√	√√
In vitro differentiation	√√	√√	√√
Chimera	√√	√/-	Ethically not allowed
Germline transmission	√√	√/-	Ethically not allowed
Follow up generations	√√	--	Ethically not allowed
Transplantation of iPS cell-derived cells	√√	√/-	No clinical studies to date1

√√: Fully proven; √/-: Partially proven; --: Not achieved yet;

¹The first clinical study was recently initiated (http://www.riken.jp/en/pr/press/2013/20130730_1). iPS: Induced pluripotent stem.