High dose chemotherapy with stem cell support in the treatment of testicular cancer

Table 6 International Germ Cell Cancer Collaborative Group-2 prognostic criteria for relapsed germ cell cancer patients

Parameter	Score points
	0	1	2	3
Primary site	Gonadal	Extragonadal	-	Mediastinal non-seminoma
Prior response	CR/PRm-	PRm+/SD	PD	-
PFI, mo	> 3	≥ 3	-	-
AFP salvage	Normal	≤ 1000	> 1000
HCG salvage	≤ 1000	> 1000	-	-
LBB	No	Yes	-	-
Score sum (0-10) Regroup into categories: (0) = 0; (1 or 2) = 1; (3 or 4) = 2; (5 or more) = 3 Add histology points: Seminoma = -1; Non-seminoma or mixed = 1 Final prognostic score: -1 = Very low risk; 0 = Low risk; 1 = Intermediate risk; 2 = High risk; 3 = Very high risk

AFP: Alpha-fetoprotein; CR: Complete remission; HCG: Human chorionic gonadotrophin; LBB: Liver, brain, bone; PD: Progressive disease; PFI: Progression free interval; PRm-: Partial remission, markers negative; PRm+: Partial remission, markers positive; SD: Stable disease.