High dose chemotherapy with stem cell support in the treatment of testicular cancer

Table 5 High dose chemotherapy for extragodadal germ cell cancer

Ref.	Type of study	Number of patients	Setting	Protocol	OS (%)	PFS (%)	Medianfollow-up (mo)
Bokemeyer et al[44]	Phase I/II, prospective	28	PMNSGCT, first line	VIPx 1 + HD-VIP × 3	64 (5 yr)	56 (5 yr)	43
Banna et al[45]	Prospective	21	PMNSGCT, first line	BEP or VIP × 4 + HD-CEC × 1	41 (3 yr)	43 (5 yr)	52
Rosti et al[46]	Retrospective	22	EGCT, poor prognosi, first line	Various	75 (5 yr)	67 (5 yr)	50
Hartmann et al[47]	Retrospective	142	EGNSGCT, salvage	Various	12 (3 yr) (PMNSGCT only)	11 (3 yr) (PMNSGCT only)	45
De Giorgi et al[48]	Retrospective	59	EGNSGCT, salvage	Various	14 (PMNSGCT only)	14 (PMNSGCT only)	58

EGCT: Extragonadal germ cell tumor; EGNSGCT: Extragonadal non-seminomatous germ cell tumor; HD: High dose; HD-CEC: High dose carboplatin, etoposide, cyclophosphamide; HDCT: High dose chemotherapy; HD-ICE: High dose ifosfamide, carboplatin, etoposide; NR: Not reported; OS: Overall survival; PFS: Progression-free survival; PMNSGCT: Primary mediastinal non-seminomatous germ cell tumor.