High dose chemotherapy with stem cell support in the treatment of testicular cancer

doi:10.4252/wjsc.v7.i11.1222

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World Journal of Stem Cells

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Dec 26, 2015; 7(11): 1222-1232
Published online Dec 26, 2015. doi: 10.4252/wjsc.v7.i11.1222

Table 2 Studies of first line high dose chemotherapy for poor prognosis patients

Ref.	Type of study	Number of patients	Protocol	OS (%)	PFS (%)	Medianfollow-up (mo)
Motzer et al[15]	Phase II, prospective	28	VAB-6 × 2 + HD-CE × 2	57	46	31
Motzer et al[16]	Phase II, prospective	30	VIP × 2 + HD-CEC × 2	48 (5 yr)	48 (5 yr)	60
Bokemeyer et al[17]	Comparative, retrospective	147 (HDCT) vs 309 (SDCT)	VIP × 2 + HD-VIP × 2 vs BEP/VIP × 4	82 vs 72 (2 yr) P = 0.0184	75 vs 59 (2 yr) P = 0.0056	21
Schmoll et al[18]	Phase I/II, prospective	221	VIP + HD-VIP × 3-4	73 (5 yr)	68 (5 yr)	48
Hartmann et al[19]	Phase I/II, prospective	52	VIP + T-HD-VIP	75 (5 yr)	64 (5 yr)	41
Motzer et al[20]	Phase III, prospective	108 (HDCT) vs 111 (SDCT)	BEP × 2 + HD-CEC × 2 vs BEP × 4	71 vs 72 (2 yr)	60 vs 57 (2 yr)	33
Daugaard et al[23]	Phase III, prospective	65 (HDCT) vs 66 (SDCT)	VIP + HD-VIP × 3 vs BEP × 4	86.1 vs 83 (2 yr)	66.1 vs 48 (1 yr)	NR
Necchi et al[22]	Phase II, prospective	43 (HDCT) vs 42 (SDCT)	BEP × 2 + HD-CpE + HD-Carbo vs BEP × 4	54.8 vs 55.8 (5 yr)	59.3 vs 62.8 (5 yr)	114

BEP: Bleomycin, etoposide, cisplatin; HD: High dose; HD-CE: High dose carboplatin, etoposide; HD-CEC: High dose carboplatin, etoposide, cyclophosphamide; HDCT: High dose chemotherapy; HD-VIP: High dose, etoposide, ifosfamide, cisplatin; NR: Not reported; OS: Overall survival; PFS: Progression free survival; SDCT: Standard-dose chemotherapy; VAB: Actinomycin D, vinblastine, cyclophosphamide, bleomycin, cisplatin.

Citation: Popovic L, Matovina-Brko G, Popovic M, Petrovic D, Cvetanovic A, Vukojevic J, Jovanovic D. High dose chemotherapy with stem cell support in the treatment of testicular cancer. World J Stem Cells 2015; 7(11): 1222-1232
URL: https://www.wjgnet.com/1948-0210/full/v7/i11/1222.htm
DOI: https://dx.doi.org/10.4252/wjsc.v7.i11.1222