High dose chemotherapy with stem cell support in the treatment of testicular cancer

Table 1 Prognostic criteria for metastatic germ cell tumors[3]

	Good prognosis group	Intermediate prognosis group	Poor prognosis group
Seminoma	90% of cases 5 yr PFS 82% 5 yr OS 86% All of the following criteria: Any primary site No non-pulmonary visceral metastases Normal AFP Any hCG Any LDH	10% of cases 5 yr PFS 67% 5 yr OS 72% Any of the following criteria: Any primary site Non-pulmonary visceral metastases Normal AFP Any hCG Any LDH	-
Non-seminoma	56% of cases 5 yr PFS 89% 5 yr OS 92% All of the following criteria: Testis/retroperitoneal primary Non non-pulmonary visceral metastases AFP < 1000 ng/mL hCG < 5000 IU/L (1000 ng/mL) LDH < 1.5 × ULN	28% of cases 5 yr PFS 75% 5 yr OS 80% Testis/retroperitoneal primary Non non-pulmonary visceral metastases AFP 1000-10000 ng/mL hCG 5000-50000 IU/L (1000 ng/mL) LDH 1.5-10 × ULN	28% of cases 5 yr PFS 75% 5 yr OS 80% Any of the following criteria: Mediastinal primary Non-pulmonary visceral metastases AFP > 10000 ng/mL hCG > 50000 IU/L (1000 ng/mL) LDH > 10 × ULN

AFP: Alpha-fetoprotein; hCG: Human chorionic gonadotrophin; LDH: Lactate dehydrogenase; PFS: Progression free survival; OS: Overall survival.