Regulated genes in mesenchymal stem cells and gastric cancer

doi:10.4252/wjsc.v7.i1.208

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Jan 26, 2015; 7(1): 208-222
Published online Jan 26, 2015. doi: 10.4252/wjsc.v7.i1.208

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Figure 6 Notch signaling and the epithelial-mesenchymal transition hypothesis. A: Upon cellular stimulation by the Notch ligand, the intracellular domain of the Notch receptor (NICD) translocates into the nucleus and regulates gene transcription; B: In the EMT hypothesis, epithelial-phenotype cells expressing NOTCH1 transition to mesenchymal-phenotype cells expressing NOTCH2. RGS1: Regulator of G-protein signaling 1; EMT: Epithelial-mesenchymal transition; JAG2: Jagged 2; CSCs: Cancer stem cells.

Citation: Tanabe S, Aoyagi K, Yokozaki H, Sasaki H. Regulated genes in mesenchymal stem cells and gastric cancer. World J Stem Cells 2015; 7(1): 208-222
URL: https://www.wjgnet.com/1948-0210/full/v7/i1/208.htm
DOI: https://dx.doi.org/10.4252/wjsc.v7.i1.208