Regulated genes in mesenchymal stem cells and gastric cancer

Figure 5 Gene expression of NOTCH, delta-like 1 (Drosophila) (DLL1) and JAG. A: The gene expression of NOTCH1, 3 and 4 was up-regulated in diffuse-type gastric cancer (GC) compared with mesenchymal stem cell (MSCs), whereas NOTCH2 was down-regulated. Results represent the mean ± SE (n = 12 in MSC cultures and n = 5 in diffuse-type GC). ^aP < 0.05, ^bP < 0.01, and ^dP < 0.001 using Student’s t test; B: DLL1, a NOTCH ligand, was up-regulated in diffuse-type GC compared with MSCs. Results represent the mean ± SE (n = 12 in MSC cultures and n = 5 in diffuse-type GC). ^bP < 0.01 using Student’s t test; C: Jagged 2 (JAG2), a NOTCH ligand, was up-regulated in diffuse-type GC compared with MSCs. Jagged 1 (JAG1) was up-regulated in diffuse-type GC compared with MSCs. Results represent the mean ± SE (n = 12 in MSC cultures and n = 5 in diffuse-type GC). ^aP < 0.05 and ^bP < 0.01 using Student’s t test.