Regulated genes in mesenchymal stem cells and gastric cancer

Figure 4 Gene expression of stem cell-related genes. A: The gene expression of growth arrest-specific 6 (GAS6) was down-regulated in diffuse-type gastric cancer (GC) compared with mesenchymal stem cell (MSCs). Results represent the mean ± SE (n = 12 in MSC and n = 5 in diffuse-type GC). ^bP < 0.001 using Student’s t test; B: The gene expression of musashi RNA-binding protein 2 (MSI2) was up-regulated in diffuse-type GC compared with MSCs. Results represent the mean ± SE (n = 12 in MSC and n = 5 in diffuse-type GC). ^aP < 0.05, ^bP < 0.01, and ^dP < 0.001 using Student’s t test; C: The gene expression of hairy and enhancer of split 1 (Drosophila) (HES1) was up-regulated in diffuse-type GC compared with MSCs. Results represent the mean ± SE (n = 12 in MSC and n = 5 in diffuse-type GC). ^bP < 0.01 and ^dP < 0.001 using Student’s t test. All three genes have stem cell terms in the Gene Ontology biological process.