Early gestation chorionic villi-derived stromal cells for fetal tissue engineering

Figure 4 Robust paracrine secretion by placenta-derived mesenchymal stromal cells. A, C: Results from the human angiogenesis array kit detected 30 secreted factors with integrated density values above 10³. A: Original membrane image from the Angiogenesis array, and C: corresponding graph showing measured integrated density values of detected spots. Functions of proteins identified here include modulation of angiogenesis, chemotaxis, stimulation of cell proliferation, blood vessel maturation, blood coagulation, and extracellular matrix remodeling. B, D: Results from the panel A array kit detected 7 secreted factors with integrated density values above 10³. B: Original membrane image from the Panel A array; D: Corresponding graph showing measured integrated density values of detected spots. Many of these proteins have distinct functions related to the cell chemotaxis and immune response. TGF: Transforming growth factor; IL:Interleukin; VEGF: Vascular endothelial growth factor; GROα: Growth regulated oncogene alpha; MCP-1: Monocyte chemotactic protein 1; uPA: Urokinase-type plasminogen activator.