Obesity and weight loss could alter the properties of adipose stem cells?

Figure 2 Multipotent stem cells as key players in tissue homeostasis disruption in obesity. The enormous increase in subcutaneous fat mass leads to an increase in secreted molecules such as monocyte chemotactic protein 1 (MCP-1), which causes monocyte infiltration and subsequent macrophage differentiation (blue lines). Inflammatory cytokines may change multipotent stem cells to a non-healthy phenotype (blue lines) that in turn impairs (red lines) the normal adipogenesis of subcutaneous adipose tissue.