Epigenetic therapy of cancer stem and progenitor cells by targeting DNA methylation machineries

Figure 1 High similarity of critical amino acid residues at the catalytic domain of DNA methyltransferases. Multiple alignment of amino acids within the catalytic domain of three catalytically active human DNA methyltransferases DNMT1, DNMT3A and DNMT3B is shown. Highlighted amino acids with roman letters shown above indicate critical residues of the catalytic domain. DNMT: DNA methyltransferases.