Current progress in use of adipose derived stem cells in peripheral nerve regeneration

Table 4 Animal studies modelling adipose derived stem cells and conduits for peripheral regeneration

Animal models	Details	Measured outcomes	Ref.
Rat	Polycaprolactone conduit for 6 mm nerve gap	SNI, nerve thickness	[56]
Rat	Fibrin conduit 10 mm nerve gap	Axon regeneration	[42]
Rat	Polyhydroxybutyrate conduit 10 mm nerve gap	Axon regeneration	[59]
Mouse	Nerve crush model and local administration ADSC ± matrigel	Axon regeneration	[48]
Rat	Decellularised vascular conduit v autogenous nerve and vascular conduits containing ADSC	Axon regeneration, nerve conduction velocity	[90]
Rat	Silastic conduit for 13 mm nerve gap	SNI, EPT, sensory nerve function	[57]
Rat	Silicon conduit ± collagen or ADSCs	Axon regeneration, nerve conduction velocity	[100]
Rat	Nerve crush model with systemic injection of ADSC	Axon regeneration, motor recovery	[68]
Rat	Genipin-Gelatin-Tricalcium phosphate conduit 10 mm nerve gap	SNI	[92]
Rat	ADSC injected into repaired chronic denervated nerve	Axon regeneration, PFI	[89]
Rat	Microporous conduit for 15 mm nerve gap	Motor recovery	[60]
Rat	Fibrin conduit for 10 mm nerve gap	Motor recovery, GAP-43 expression in dorsal root ganglion	[58]
Dog	Polytetrafluoroethylene tube and alginate hydrogel l 7 mm nerve gap	Axon regeneration	[51]

ADSC: Adipose derived stem cell; SNI: Sciatic nerve index; GAP-43: Growth associated protein.