Fetal vs adult mesenchymal stem cells achieve greater gene expression, but less osteoinduction

doi:10.4252/wjsc.v7.i1.223

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Jan 26, 2015 (publication date) through Nov 4, 2024

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Jan 26, 2015; 7(1): 223-234
Published online Jan 26, 2015. doi: 10.4252/wjsc.v7.i1.223

Table 2 Summary data of the analysis of the microradiographs

Treatment group	Total thighs(n)	Thighs with new bone[n (%) of total]	Mean ossiclearea (mm²)	Mean extent ofperiosteal new bone	Mean midshaftdiameter (mm ± SD)
Saline	4	0	0	0	1.24 ± 0.07
Ad-BMP2-aMSC	6	5 (83)^a	0.78	1	1.57 ± 0.35^c
aMSC	4	0	0	0	1.26 ± 0.09
Ad-BMP2-fMSC	6	1 (17)	0.45	0	1.27 ± 0.08
fMSC	4	0	0	0	1.23 ± 0.07

^aP < 0.05 Ad-BMP2-aMSC vs Ad-BMP2-fMSC;

^cP < 0.05 intergroup comparison. BMP2: Bone morphogenic protein 2; MSCs: Mesenchymal stem cells; Ad-GFP: E1-A-deleted-green fluorescent protein; fMSCs: Fetal mesenchymal stem cells; aMSCs: Adult mesenchymal stem cells.

Citation: Santiago-Torres JE, Lovasz R, Bertone AL. Fetal vs adult mesenchymal stem cells achieve greater gene expression, but less osteoinduction. World J Stem Cells 2015; 7(1): 223-234
URL: https://www.wjgnet.com/1948-0210/full/v7/i1/223.htm
DOI: https://dx.doi.org/10.4252/wjsc.v7.i1.223