Regulated genes in mesenchymal stem cells and gastric cancer

Table 1 Gene expression alterations of regulator of G-protein signaling family genes in mesenchymal stem cells and diffuse-type gastric cancer

Gene symbol	Detailed description	P value	Ratio of diffuse-type GC to MSCs	Probe set ID
RGS1	Immune response / signal transduction / adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway / negative regulation of signal transduction / termination of G-protein coupled receptor signaling pathway / positive regulation of GTPase activity	0.013	1004	202988_s_at
		0.001	13808	216834_at
RGS2	Regulation of translation / cell cycle / spermatogenesis / regulation of G-protein coupled receptor protein signaling pathway / negative regulation of signal transduction / negative regulation of phospholipase activity / negative regulation of cardiac muscle hypertrophy / termination of G-protein coupled receptor signaling pathway / negative regulation of mitogen-activated protein (MAP) kinase activity / positive regulation of GTPase activity / negative regulation of G-protein coupled receptor protein signaling pathway / brown fat cell differentiation / relaxation of cardiac muscle / relaxation of vascular smooth muscle / positive regulation of cardiac muscle contraction / regulation of adrenergic receptor signaling pathway	0.007	14.51	202388_at
RGS3	Inactivation of mitogen-activated protein kinase (MAPK) activity / signal transduction / regulation of G-protein coupled receptor protein signaling pathway / negative regulation of signal transduction / termination of G-protein coupled receptor signaling pathway / positive regulation of GTPase activity	1.00E-05	0.39	203823_at
RGS4	Inactivation of MAPK activity / regulation of G-protein coupled receptor protein signaling pathway / negative regulation of signal transduction / termination of G-protein coupled receptor signaling pathway / positive regulation of GTPase activity	3.00E-04	0.17	204337_at
		0.003	0.11	204338_s_at
		0.004	0.14	204339_s_at
RGS5	Signal transduction / regulation of G-protein coupled receptor protein signaling pathway / negative regulation of signal transduction / termination of G-protein coupled receptor signaling pathway / positive regulation of GTPase activity	0.01	47.79	209070_s_at
		0.008	81.82	209071_s_at
		0.009	95.52	218353_at
RGS10	Negative regulation of signal transduction / termination of G-protein coupled receptor signaling pathway / positive regulation of GTPase activity	0.003	3.92	204319_s_at
RGS19	Autophagy / G-protein coupled receptor signaling pathway / small GTPase mediated signal transduction / negative regulation of signal transduction / termination of G-protein coupled receptor signaling pathway / positive regulation of GTPase activity	9.00E-04	2.45	204336_s_at

RGS family genes that have significant alterations in MSCs and diffuse-type GC are shown. RGS1, RGS2, RGS5, RGS10 and RGS19 were up-regulated in diffuse-type GC compared with MSCs. RGS3 and RGS4 were down-regulated in diffuse-type GC compared with MSCs. RGS: Regulator of G-protein signaling; MSCs: Mesenchymal stem cells; GC: Gastric cancer.