Adult human neural stem cell therapeutics: Current developmental status and prospect

doi:10.4252/wjsc.v7.i1.126

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World Journal of Stem Cells

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Jan 26, 2015; 7(1): 126-136
Published online Jan 26, 2015. doi: 10.4252/wjsc.v7.i1.126

Table 3 Current clinical trials of neural stem cells against neurodegenerative diseases

Disease	NSC source	Brief title	Trial ID	Condition	Location	Period	Cell source	Route	Phase
ALS	Fetal NSCs	Human neural stem cell transplantation in amyotrophic lateral sclerosis	NCT01640067	Recruiting	Italy	2011-12 -2016-09	Fetal neural stem cells	Spinal cord	I
		Dose escalation and safety study of human spinal cord derived neural stem cell transplantation for the treatment of amyotrophic lateral sclerosis	NCT01730716	Ongoing	United States	2013-05 -2014-09	Spinal cord of a single fetus 8 wk of gestation	Spinal cord after laminectomy	II
		Human spinal cord derived neural stem cell transplantation for the treatment of amyotrophic lateral sclerosis	NCT01348451	Ongoing	United States	2009-01 -2015-12	Spinal cord of a single fetus 8 wk of gestation	Spinal cord after laminectomy	I
Stoke	Adult NSCs	Pilot investigation of stem cells in stroke	NCT01151124	Ongoing	United Kingdom	2010-06 -2015-03	CTX0E03 DP allogeneic neural stem cells	Putamen region of the brain	I
Stoke		Pilot Investigation of stem cells in stroke phase II efficacy	NCT02117635	Recruiting	United Kingdom	2014-06 -2015-12	CTX0E03 DP allogeneic neural stem cells	Intracranially via stereotaxic	II
SCI	Adult NSCs	Safety study of human spinal cord-derived neural stem cell transplantation for the treatment of chronic SCI	NCT01772810	Recruiting	United States	2014-08 -2016-02	Human spinal cord-derived neural stem cell	Direct injections into spinal parenchyma	I
		Study of human central nervous system stem cells in patients with thoracic spinal cord Injury	NCT01321333	Ongoing	Canada, Switzerland	2011-03 -2015-05	Human central nervous system stem cells	Thoracic spinal cord	I, II
		Study of human central nervous system stem cell transplantation in cervical spinal cord injury	NCT02163876	Recruiting	United States	2014-10 -2017-05	Human central nervous system stem cells	Cervical spine	II

NSCs: Neural stem cells; ALS: Amyotrophic lateral sclerosis; iPSCs: Induced pluripotent stem cells.

Citation: Nam H, Lee KH, Nam DH, Joo KM. Adult human neural stem cell therapeutics: Current developmental status and prospect. World J Stem Cells 2015; 7(1): 126-136
URL: https://www.wjgnet.com/1948-0210/full/v7/i1/126.htm
DOI: https://dx.doi.org/10.4252/wjsc.v7.i1.126