Histone modifications: Targeting head and neck cancer stem cells

Figure 3 Data from Giudice et al[151] showing the impact of histone deacetylases inhibitor on the population of CICs. A: Fluorescence-activated cell sorting of ALDH+ cells demonstrates that HNSCC cell lines have a high number CICs, and that administration of TSA reduced total number of ALDH+ cells; B: HDACi (TSA) disrupts tumor spheres as depicted in representative images of tumor spheres and by quantification of spheres (HN6 ^bP < 0.01, HN13 ^aP < 0.05). TSA: Trichostatin A; ALDH: Aldehyde dehydrogenase; SCC: Side scatter of light; HDACi: Histone deacteylases inhibitors; HNSCC: Head and neck squamous cell carcinoma.