Secretion of immunoregulatory cytokines by mesenchymal stem cells

doi:10.4252/wjsc.v6.i5.552

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World Journal of Stem Cells

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1948-0210

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World J Stem Cells. Nov 26, 2014; 6(5): 552-570
Published online Nov 26, 2014. doi: 10.4252/wjsc.v6.i5.552

Table 1 Cytokines secreted by mesenchymal stem cells and the corresponding target cells

Cytokines secreted by MSCs	Target cells
IL-10	Mph, Neu, DCs, Th1, Tregs, Tr1, tumor cells
IL-6	Neu, Mo, DCs, B, Th2, Tregs, Th17, CD8+FoxP3+
TGFβ	Mph, NK, DCs, B, T, Tregs
Chemokines	Neu, Mo, NK, Eo, Baso, DCs, Ly
CCL-2/MCP-1	Mph, EC, PL, Th2, Th17
CCL-5/RANTES	Neu, Mo, DCs, Th1, Tregs, CD8+FoxP3+
IDO	Mo, DCs, B, T, Tregs
VEGF	DCs, EC, Th1, Th17, Tregs
ICAM	T, MSCs
PGE2	Mph, Mo, NK, DCs, T, Tr1

MSCs: Mesenchymal stem cells; TGFβ: Transforming growth factor β; CCL: CC chemokine ligand; MCP-1: Monocyte chemotactic protein 1; RANTES: Regulated on activation, normal T cell expressed and secreted; IDO: Indoleamine-2,3-dioxygenase; VEGF: Vascular endothelial growth factor; ICAM: Intercellular adhesion molecule; PGE2: Prostaglandin E2; Mph: Macrophages; Neu: Neutrophils; DCs: Dendritic cells; Th: T helpers; Tregs: T regulatory cells; Tr1: T regulatory 1; Mo: Monocytes; B: B cells; NK: Natural killers; T: T cells; Eo: Eosinophils; Baso: Basophils; Ly: Lymphocytes; EC: Endothelial cells; PL: Plasma cells.

Citation: Kyurkchiev D, Bochev I, Ivanova-Todorova E, Mourdjeva M, Oreshkova T, Belemezova K, Kyurkchiev S. Secretion of immunoregulatory cytokines by mesenchymal stem cells. World J Stem Cells 2014; 6(5): 552-570
URL: https://www.wjgnet.com/1948-0210/full/v6/i5/552.htm
DOI: https://dx.doi.org/10.4252/wjsc.v6.i5.552