Early B lymphocyte development: Similarities and differences in human and mouse

Figure 3 The role of signaling molecules in B lymphopoiesis. Several cytokines, such as stem cell factor (SCF), Flt3 ligand and IL-7, show the various effects depending on the developmental stages. There are several species differences in the role of cytokines between human and mouse. IL-7 is required for adult mouse B lymphopoiesis, but not for that of human. Recent studies indicate that Flt3 signaling plays a crucial role in lymphoid, but not in HSC or myeloid development in mouse, while human Flt3 ligand affects the survival of hematopoietic stem/ progenitor cells as well as B cell differentiation. HSC: Hematopoietic stem cells; MPP: Multipotent progenitors; LMPP/ELP: Lymphoid-primed multipotent/early lymphoid progenitors.