Advances in haplo-identical stem cell transplantation in adults with high-risk hematological malignancies

Figure 1 Example of a potential donor search algorithm that aims to expedite finding a suitable stem cell donor. A blend of high and low resolution approaches are employed. In certain situations the likelihood of finding an un-related donor match is low due to rare alleles and haplotypes. Consideration of a haplo-identical BMT may be considered at an earlier stage. Abbreviations: HR: High resolution (allele level); LR: Low resolution (antigen level); NIMA: Non-inherited maternal antigen; KIR: Killer cell Ig-like receptors; DSA: Donor-specific antibodies; BMT: Bone marrow transplant.