Fetal stem cell transplantation: Past, present, and future

Table 2 Ongoing clinical trials of embryonic stem cell-derived cell transplantation

Clinical Trials.gov	Start (yr)	Sponsor	Status	Title	Condition	Intervention	Remarks
NCT01344993	2011	Advanced cell technology	Recruiting	Safety and tolerability of transplantation of MA09-hRPE cells in patients with advanced dry age related macular degeneration	Advanced dry age related macular degeneration	Sub-retinal transplantation of MA09-hRPE	A Phase I/II, open-label, multi-center, prospective study in United States. MA09-hRPE cells are human embryonic stem cell derived retinal Pigmented epithelial cells.
NCT01345006	2011	Advanced cell technology	Recruiting	Transplantation of MA09-hRPE cells in patients with stargardt's macular dystrophy	Stargardt's macular dystrophy	Sub-retinal transplantation of MA09-hRPE	A Phase I/II, open-label, multi-center, prospective study in United States
NCT01469832	2011	Advanced cell technology	Recruiting	Safety and tolerability of transplantation of hESC-RPE cells in patients with stargardt's macular dystrophy	Stargardt's macular dystrophy; fundus flavimaculatus; juvenile macular dystrophy	Sub-retinal transplantation of MA09-hRPE	A PhaseI/II, open-label, multi-center, prospective study in the United States
NCT01625559	2012	CHA Bio and diostech	Recruiting	Safety and tolerability of MA09-hRPE cells in patients with stargardt's macular dystrophy	Stargardt's macular dystrophy	Sub-retinal transplantation of MA09-hRPE	A Phase I, open-label, prospective study in Korea
NCT01674829	2012	CHA Bio and diostech	Recruiting	Safety and tolerability of transplantation of MA09-hRPE cells in patients with advanced dry age-related macular degeneration (AMD)	Dry age Related macular degeneration	Sub-retinal transplantation of MA09-hRPE	A Phase I/IIa, open-label, single-center, prospective study in Korea
NCT01691261	2014	Pfizer	Not yet recruiting	Implantation of human embryonic stem cell derived retinal pigment epithelium in subjects with acute wet age related macular degeneration and recent rapid vision decline	Age related macular degeneration	Implantation of human embryonic stem cell derived retinal pigment epithelium	Phase 1, open-label, safety and feasibility study in United Kingdom. PF-05206388 is human embryonic stem cell derived retinal pigment epithelium living tissue equivalent.
NCT02057900	2013	Assistance publique - hôpitaux de Paris	Recruiting	Transplantation of human embryonic stem cell-derived progenitors in severe heart failure (ESCORT)	Ischemic heart disease	Human embryonic stem cell-derived CD15+ Isl-1+ progenitors	Phase 1, open-label, feasibility and safety study in France
NCT02122159	2014	University of California, Los Angeles	Not yet recruiting	Research with retinal cells derived from embryonic stem cells for myopic macular degeneration	Myopic macular degeneration	MA09-hRPE cellular therapy	A Phase I/II, Open-label, prospective study to determine the safety and tolerability in United States

The survey was conducted in ClinicalTrials.gov using key words “Embryonic + Stem + Cells”. The status of clinical trials listed is confirmed on June 19, 2014. The description of the table is based on the database. See the details by entering the identifier No. into the database website.