Sox2, a key factor in the regulation of pluripotency and neural differentiation

Figure 1 Sex determining region Y-box 2 regulates gene expression in pluripotent stem cells and neural progenitor/stem cells. Sex determining region Y-box 2 (Sox2) interacts with Oct4 and other nuclear factors to activate pluripotent gene expression and repress differentiation gene expression in pluripotent stem cells. In neural progenitor/stem cells, Sox2 interacts with neural transcription factors, such as Brn2 and Pax6, to activate neural progenitor gene expression. Oct4: Octamer-binding transcription factor 4; Pax6: Paired-box protein 6.