Familial Alzheimer’s disease modelling using induced pluripotent stem cell technology

Figure 1 Isolation of disease specific induced pluripotent stem cells. Reprogramming of dermal fibroblasts from patients with Alzheimer’s disease into induced pluripotent stem cells provides an infinite source of cells to apply directed differentiation protocols to generate disease-specific neurons that exhibit phenotypic disease traits. This presents a unique opportunity to utilise these cells in the exploitation of drug discovery, disease modelling and personalised medicine.