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Copyright ©2014 Baishideng Publishing Group Co.
World J Stem Cells. Apr 26, 2014; 6(2): 213-229
Published online Apr 26, 2014. doi: 10.4252/wjsc.v6.i2.213
Figure 3
Figure 3 Causative factors in celiac disease. The pathogenesis of celiac disease involves: (1) host genetic background (HLA-DQ2 or DQ8 and other non-HLA genes); (2) an external trigger (gluten); and (3) environmental cofactors (such as intestinal pathogens, altered gut microbiota composition, infant-feeding practices and some immune-modulatory drugs).