Differentiation of mesenchymal stem cells into gonad and adrenal steroidogenic cells

doi:10.4252/wjsc.v6.i2.203

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Apr 26, 2014 (publication date) through Nov 28, 2024

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Apr 26, 2014; 6(2): 203-212
Published online Apr 26, 2014. doi: 10.4252/wjsc.v6.i2.203

Table 1 Summary of the characteristics of steroidogenic factor-1 and liver receptor homolog-1

Nuclear receptor	Expressing tissues	Function	Phenotypes of knockout mice
SF-1/Ad4BP/NR5A1	Testis, ovary, adrenal,	Steroidogenesis Sex differentiation Energy homeostasis	Adrenal and gonadal agenesis
			Sex reversal in external genitalia
			Impaired expression of pituitary gonadotropins
			Abnormality of ventromedial hypothalamic nucleus
LRH-1/NR5A2	Ovary, testis, liver, pancreas, intestine, early embryo	Steroidogenesis Ovulation Bile acid synthesis Glucose metabolism	Embryonic lethal around E6.5-7.5 d

Citation: Yazawa T, Imamichi Y, Miyamoto K, Umezawa A, Taniguchi T. Differentiation of mesenchymal stem cells into gonad and adrenal steroidogenic cells. World J Stem Cells 2014; 6(2): 203-212
URL: https://www.wjgnet.com/1948-0210/full/v6/i2/203.htm
DOI: https://dx.doi.org/10.4252/wjsc.v6.i2.203