Neurotrauma and mesenchymal stem cells treatment: From experimental studies to clinical trials

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Apr 26, 2014 (publication date) through Jul 24, 2024

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Apr 26, 2014; 6(2): 179-194
Published online Apr 26, 2014. doi: 10.4252/wjsc.v6.i2.179

Table 3 Summary of pre-clinical and clinical studies using mesenchymal stem cell for peripheral nerve injury

Animal	Nerve	Lesion type	Cells source	Route of administration	Ref.
Mouse	Median	Transection	Bone marrow-MSC	Local	[147]
Mouse	Ischiatic	Transection	Bone marrow-MSC	Local	[148]
Mouse	Ischiatic	Transection	Embryonic stem cell derived-MSC	Local	[144]
Mouse	Ischiatic	Crush	Adipose derived-MSC	Intravenous	[149]
Mouse	Ischiatic	Transection	Bone marrow-MSC	Local	[131]
Rat	Ischiatic	Crush	Amniotic fluid derived-MSC	Local	[150]
Rat	Ischiatic	Crush	Amniotic fluid derived-MSC	Intravenous	[151-153]
Rat	Facial	Transection	Bone marrow-MSC	Local	[154,155]
Rat	Ischiatic	Crush	Bone marrow-MSC	Local	[156]
Rat	Ischiatic	Transection	Adipose derived-MSC	Local	[157-159]
Rat	Ischiatic	Transection	Umbilical cord derived-MSC	Local	[160,161]
Rat	Ischiatic	Transection	Bone marrow-MSC	Local	[145,158,162-169]
Rat	Cavernous	Traction	Bone marrow-MSC	Intracavernousal injection	[170]
Rabbit	Facial	Transection	Bone marrow-MSC	Local	[171]
Rabbit	Ischiatic	Traction	Bone marrow-MSC	Local	[172,173]
Pig	Ischiatic	Transection	Bone marrow-MSC	Local	[174]
Dog	Ischiatic	Transection	Bone marrow-MSC	Local	[140,175]
Dog	Ischiatic	Transection	Adipose derived-MSC	Local	[176]
Monkey	Median	Transection	Bone marrow-MSC	Local	[142]
Human	Median or ulnar	Transection	Bone marrow mononuclear cell fraction-MSC	Local	[146]

MSC: Mesenchymal stem cell.

Citation: Martinez AMB, Goulart CO, Ramalho BDS, Oliveira JT, Almeida FM. Neurotrauma and mesenchymal stem cells treatment: From experimental studies to clinical trials. World J Stem Cells 2014; 6(2): 179-194
URL: https://www.wjgnet.com/1948-0210/full/v6/i2/179.htm
DOI: https://dx.doi.org/10.4252/wjsc.v6.i2.179