Neurotrauma and mesenchymal stem cells treatment: From experimental studies to clinical trials

doi:10.4252/wjsc.v6.i2.179

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World Journal of Stem Cells

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1948-0210

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World J Stem Cells. Apr 26, 2014; 6(2): 179-194
Published online Apr 26, 2014. doi: 10.4252/wjsc.v6.i2.179

Table 2 Summary of clinical trials studies using mesenchymal stem cell for spinal cord injury

Title	Lesion type	Cells source	Phase of the study	Status	Effects on CNS regeneration
Clinical study of treatment for acute SCI using cultured bone marrow stromal cells	Cervical SCI	Autologous Bone marrow-MSC	Terminated	1/2	Rapid and remarkable recovery of ASIA B and C patients, but gradual or limited in ASIA A patients.
Autologous mesenchymal stem cell in SCI patients	Complete cervical or thoracic SCI	Autologous bone marrow-MSC	Enrolling by invitation	2	Not informed
Different efficacy between rehabilitation therapy and umbilical cord derived MSCs transplantation in patients with chronic SCI in China	Traumatic SCI	Umbilical cord derived-MSC	Recruiting	3	Not informed
A phase III/IV clinical trial to evaluate the safety and efficacy of bone marrow-derived MSC transplantation in patients with chronic SCI	Cervical SCI	Autologous bone marrow-MSC	Recruiting	1/2	Not informed
Phase I/II trial of autologous bone marrow derived MSCs to patients with SCISafety of autologous adipose derived MSCs in patients with SCI	Traumatic thoracic or lumbar SCIClinical diagnosis of SCI (ASIA A to C)	Autologous bone marrow-MSCAutologous Adipose derived-MSC	RecruitingCompleted	1/21	Not informed
The effect of intrathecal transplantation of autologous adipose tissue derived MSCs in the patients with SCI, phase I clinical study	Clinical diagnosis of SCI	Autologous Adipose derived-MSC	Recruiting	1	Not informed
Phase I, single center, trial to assess safety and tolerability of the intrathecal infusion of ex-vivo expanded bone-marrow derived MSCs for the treatment of SCI	Clinical diagnosis of SCI (ASIA A)	Autologous bone marrow-MSC	Active, not recruiting	1	Not informed
Study the safety and efficacy of bone marrow derived autologous cells for the treatment of SCI	Clinical diagnosis of SCI	Autologous bone marrow-MSC	Recruiting	1/2	Not informed
Surgical transplantation of autologous bone marrow stem cells with glial scar resection for patients of chronic SCI and intra-thecal injection for acute and subacute injury-a preliminary study	Complete spinal cord trans-section	Autologous bone marrow-MSC	Completed	1/2	Not informed
To study the safety and efficacy of autologous bone marrow stem cells in patients with SCI	SCI below C5 (ASIA A to C)	Autologous bone marrow-MSC	Recruiting	1/2	Not informed
Safety of autologous stem cell treatment for SCI in children	Clinical diagnosis of SCI (ASIA A to D)	Bone marrow-MSC	Recruiting	1	Not informed
Autologous bone marrow derived cell transplant in SCI patients	Traumatic SCI	Autologous bone marrow-MSC	Completed	1/2	Not informed

Phase 1 study of autologous bone marrow stem cell transplantation in patients with SCI	Traumatic thoracic or lumbar SCI	Autologous bone marrow-MSC	Not informed	1	Not informed
Phase I pilot study to evaluate the security of local Administration of autologous stem cells obtained from the bone marrow stroma, in traumatic injuries of the spinal cord	Traumatic SCI between C3 and L1	Autologous bone marrow-MSC	Recruiting	1	Not informed
Feasibility and safety of umbilical cord blood cell transplant into injured spinal cord: an open-labeled, dose-escalating clinical trial	Chronic SCI between C5 and T11 (ASIA A)	Umbilical cord blood mononuclear derived-MSC	Active, not recruiting	1/2	Not informed
Efficacy difference between rehabilitation therapy and umbilical Cord derived transplantation in patients with acute or chronic SCI in China	Clinical diagnosis of SCI	Umbilical cord derived-MSC	Not informed	2	Not informed
Safety and feasibility of umbilical cord blood cell Transplant Into Injured Spinal cord: an open-labeled, dose-escalating clinical trial	Chronic SCI between C5 and T11 (ASIA A)	Umbilical cord derived-MSC	Active, not recruiting	1/2	Not informed
Safety and effect of lithium, umbilical cord blood cells and the combination in the treatment of acute and sub-acute spinal cord injury : a randomized, double-blinded placebo-controlled clinical trial	Acute or Subacute traumatic SCI between C5 and T11 (ASIA A)	Umbilical cord derived-MSC	Active, not recruiting	1/2	Not informed

MSC: Mesenchymal stem cell; CNS: Central nervous system; SCI: Spinal cord injury.

Citation: Martinez AMB, Goulart CO, Ramalho BDS, Oliveira JT, Almeida FM. Neurotrauma and mesenchymal stem cells treatment: From experimental studies to clinical trials. World J Stem Cells 2014; 6(2): 179-194
URL: https://www.wjgnet.com/1948-0210/full/v6/i2/179.htm
DOI: https://dx.doi.org/10.4252/wjsc.v6.i2.179