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World J Stem Cells. Apr 26, 2014; 6(2): 120-133
Published online Apr 26, 2014. doi: 10.4252/wjsc.v6.i2.120
Published online Apr 26, 2014. doi: 10.4252/wjsc.v6.i2.120
Source of MSC | Main pathological features improved/repaired | Limitations/recommendations/conclusions | Ref. |
Human | Survival of transplanted HUMSCs 16 wk, secretion of human neutrophil-activating protein-2, neurotrophin-3, basic fibroblast growth factor, glucocorticoid induced tumor necrosis factor receptor, and vascular endothelial growth factor receptor 3 in the host spinal cord | Transplantation of HUMSCs is beneficial to wound healing after SCI in rats | Yang et al[82], 2008 |
Axonal regeneration, neuroprotective action by grafted cells, functional recovery | Co-grafted HUMSCs and BDNF may be a potential therapy for SCI | Zhang et al[83], 2009 | |
hUCMSCs survive, migrate, and produce GDNF and neurotrophin-3, functional recovery | Studies on dose-dependent effects of hUCMSCs transplantation on SCI are required | Hu et al[84], 2010 | |
Increased intensity of 5-HT fibers, increased volume of spared myelination, decreased area of cystic cavity, functional recovery | NT-3 enhanced therapeutic effects of HUMSCs after clip injury of the spinal cord. | Shang et al[85], 2011 |
- Citation: Dasari VR, Veeravalli KK, Dinh DH. Mesenchymal stem cells in the treatment of spinal cord injuries: A review. World J Stem Cells 2014; 6(2): 120-133
- URL: https://www.wjgnet.com/1948-0210/full/v6/i2/120.htm
- DOI: https://dx.doi.org/10.4252/wjsc.v6.i2.120