Mesenchymal stem cells in the treatment of spinal cord injuries: A review

doi:10.4252/wjsc.v6.i2.120

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Apr 26, 2014; 6(2): 120-133
Published online Apr 26, 2014. doi: 10.4252/wjsc.v6.i2.120

Table 6 Overview of effects of Wharton’s jelly/umbilical cord matrix cells after spinal cord injury

Source of MSC	Main pathological features improved/repaired	Limitations/recommendations/conclusions	Ref.
Human	Survival of transplanted HUMSCs 16 wk, secretion of human neutrophil-activating protein-2, neurotrophin-3, basic fibroblast growth factor, glucocorticoid induced tumor necrosis factor receptor, and vascular endothelial growth factor receptor 3 in the host spinal cord	Transplantation of HUMSCs is beneficial to wound healing after SCI in rats	Yang et al[82], 2008
	Axonal regeneration, neuroprotective action by grafted cells, functional recovery	Co-grafted HUMSCs and BDNF may be a potential therapy for SCI	Zhang et al[83], 2009
	hUCMSCs survive, migrate, and produce GDNF and neurotrophin-3, functional recovery	Studies on dose-dependent effects of hUCMSCs transplantation on SCI are required	Hu et al[84], 2010
	Increased intensity of 5-HT fibers, increased volume of spared myelination, decreased area of cystic cavity, functional recovery	NT-3 enhanced therapeutic effects of HUMSCs after clip injury of the spinal cord.	Shang et al[85], 2011

MSC: Mesenchymal stem cell; SCI: Spinal cord injury; hUCBSC: Human umbilical cord blood-derived mesenchymal stem cell.

Citation: Dasari VR, Veeravalli KK, Dinh DH. Mesenchymal stem cells in the treatment of spinal cord injuries: A review. World J Stem Cells 2014; 6(2): 120-133
URL: https://www.wjgnet.com/1948-0210/full/v6/i2/120.htm
DOI: https://dx.doi.org/10.4252/wjsc.v6.i2.120